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Biological and regulatory properties of Vav-3 in B cell receptor signal transduction
Reference
BBS/E/B/0000L048
Principal Investigator / Supervisor
Dr Martin Turner
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
78,574
Status
Completed
Type
Institute Project
Start date
01/07/2002
End date
30/06/2005
Duration
36 months
Abstract
Antigen recognition by lymphocytes triggers intracellular signalling pathways that are critical for the generation of a vigorous immune response. We have obtained preliminary evidence that Vav-3 is a new molecular component of this intracellular signalling pathway. Vav-3 is a guanine nucleotide exchange factor capable of promoting monomeric GTPases to their active state. We propose to test the hypothesis that Vav-3 may activate multiple signalling pathways and serve as an integrator of such pathways. This project proposes to combine molecular, cellular and genetic approaches to define the mechanism by which Vav-3 functions. This integrated approach will allow us to define the unique functions of Vav-3. A fuller understanding of the role that Vav-3 plays in antigen receptor signal transduction is anticipated to contribute to new strategies for immune manipulation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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