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Systematic assignment of function to human genes by complementation in yeast
Reference
BBS/E/B/0000L044
Principal Investigator / Supervisor
Dr James Ross Miller
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
72,792
Status
Completed
Type
Institute Project
Start date
01/04/2002
End date
31/03/2005
Duration
36 months
Abstract
Although the human genome has now been sequenced, we still do not know exactly how many genes we possess. At present we have an extremely poor or non-existent knowledge of the function of most of our genes. This Laboratory has previously demonstrated that it is possible to use baker¿s yeast, a simple microorganism with only 6000 genes, to assign function to human genes. Collections of human genes were used to rescue yeast strains which lack essential genes of known function. When rescue occurs, the human gene responsible must have a function identical or similar to the deleted yeast gene. We now wish to improve the overall procedure we originally developed. To do this we will take advantage of a publicly available repository of human genes, the Mammalian Genome Collection, this will allow us to include more human genes in our study. We have also developed higher throughput techniques for screening of yeast cells.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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