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Gene expression profiling of brain and cognitive ageing in mice
Reference
BBS/E/B/0000L037
Principal Investigator / Supervisor
Dr Lawrence Wilkinson
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
117,101
Status
Completed
Type
Institute Project
Start date
01/02/2001
End date
31/01/2005
Duration
48 months
Abstract
The work will use advanced behavioural and genomics methods to unravel the relationships between the psychological expression of ageing effects and underlying changes in the pattern of gene activity in brain. The experiments will ask questions about the extent to which ageing causes different gene activity changes in different brain areas and the precise relationships between any changes in gene expression and cognitive ageing. The experiments will also determine whether the impact of apparent beneficial practice effects on cognitive functioning in old mice are associated with particular patterns of gene activity. Understanding the molecular basis of such protective effects may help to ameliorate aspects of age-related cognitive decline.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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