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Regulation of precursor cell proliferation during B lymphocyte development

ReferenceBBS/E/B/0000L024
Principal Investigator / Supervisor Dr Inga-Lill Martensson-Bopp
Co-Investigators /
Co-Supervisors
Institution Babraham Institute
DepartmentBabraham Institute Department
Funding typeResearch
Value (£) 128,773
StatusCompleted
TypeInstitute Project
Start date 01/10/2001
End date 11/02/2005
Duration40 months

Abstract

B lymphocytes synthesise antibodies which make up our humoral immune response. Antibodies bind specifically to foreign antigens found on bacteria and viruses, which can then be disposed of by different routes. Individuals that lack antibodies are severely immuno-deficient and cannot clear the body of any infection that needs the assistance of antibodies. Antibodies can also be pathogenic, which is often the case when an antibody recognises auto (self) antigen; if severe this can lead to destruction of a particular tissue (autoimmunity). B lymphocytes can also become tumorigenic and a large proportion of adult lymphoid malignancies are of B lymphocyte origin. It follows that a greater understanding of the biological systems and processes that lead to proper development of B lymphocytes is of utmost importance. This increased understanding will provide insights that are relevant to, and can be exploited by, biomedicine.

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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