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A novel approach for conditional gene targeting: expression of CRE recombinase via PAC mediated enhancer trapping
Reference
BBS/E/B/0000L007
Principal Investigator / Supervisor
Dr Piers Emson
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
25,288
Status
Completed
Type
Institute Project
Start date
01/08/2001
End date
31/07/2003
Duration
24 months
Abstract
Gene targeting is established for the analysis of gene function and the generation of mouse models of human disease. Conditional gene targeting enables the manipulation of genes in a given tissue and at a given time. This relies on the availability of promoters to drive gene expression in the desired spatial temporal manner. There is currently a severe deficit of such promoters. This proposal outlines a novel transgenic strategy to harness promoter specificity by enhancer trapping from P1 artificial chromosome (PAC) transgenes. Proof of concept will be investigated by PAC mediated expression of reporter genes and Cre recombinase.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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