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Effects of Electromagnetic fields on intracellular calcium signalling and downstream calcuim-regulated events

Reference	BBS/E/B/0000H487
Principal Investigator / Supervisor	Dr Martin Bootman
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	38,192
Status	Completed
Type	Institute Project
Start date	01/10/2000
End date	30/09/2004
Duration	48 months

Abstract

The calcuim ion is a ubiquitous intracellular messenger. It controls a diverse array of cellular activities ranging from gene transcription to muscle contraction. Alterations of calcium homeostasis or calcium signals can have profound effects for virtually all cell types. An accumulating body of evidence has suggested that the cellular impact of extremely low frequency electromagnetic fields (ELF-EMF) is mediated by changes in the cellular calcium handling. Effects of ELF-EMF have been persistently observed over the last three decades of bioelectromagnetic research. During this time, a positive correlation between changes in calcium handling and ELF-EMF has been proposed for various tissues using different experimental conditions. These findings remain controversial since other studies have reported negative findings. This project aims to use current laboratory expertise in measuring extremely small changes in calcium in various cell states to establish whether such a connection exists. We will also investigate the putative links between ELF-EMF and cell pathologies which have been suggested.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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