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Role of the transcription factor, Pax5 in locus accessibility and tumourigenesis
Reference
BBS/E/B/0000H484
Principal Investigator / Supervisor
Dr Anne Corcoran
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
86,708
Status
Completed
Type
Institute Project
Start date
07/10/2000
End date
06/10/2006
Duration
72 months
Abstract
The protein Pax5 is over expressed in a number of B cell lymphomas and may play a causative role in this disease type. Pax5 is normally involved in cutting and pasting DNA to make antibodies. Lymphomas can occur when mistakes are made in this process. This project will make a model of Pax5 over expression to determine whether this dysregulates the antibody generation process and causes lymphomas, and the mechanisms involved.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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