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Award details
PIK signalling in Immunity and Infection
Reference
BBS/E/B/0000H329
Principal Investigator / Supervisor
Professor Klaus Okkenhaug
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
74,170
Status
Current
Type
Institute Project
Start date
01/09/2011
End date
31/08/2016
Duration
60 months
Abstract
The developed world has observed a dramatic reduction in mortality due to infections over the last century. At the same time, certain cancers, allergy and autoimmune disease are on the rise. Moreover, re-emerging and novel pathogens such as HIV, flu and various bacterial infections target vulnerable populations everywhere. As a consequence, a substantial effort is still required to find strategies to target the immune system in ways that reduce autoimmune, allergic and inflammatory diseases while retaining optimal protection from pathogens. In this programme, we will explore how experimental and eventually therapeutic modulation of the PI3K signalling module affects different components of the immune system. We will apply this knowledge to suggest how manipulation of PI3K signalling can be used to promote immunological health and improved lifespan.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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