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Identification of te RNA targets of the TIS11b and d tumour suppressors
Reference
BBS/E/B/0000H322
Principal Investigator / Supervisor
Dr Martin Turner
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
45,540
Status
Completed
Type
Institute Project
Start date
01/07/2011
End date
30/06/2013
Duration
24 months
Abstract
The control of mRNA stability and translation is widely used by cells to control proliferation, differentiation and apoptosis. The importance of post-transcriptional control is underscored by observations that it is deregulated in malignant diseases including leukaemia and lymphoma. However, our understanding of post-transcriptional control mechanisms, and their relevance to cancer, lags far behind our understanding of transcriptional regulation and signal transduction. Post transcriptional control is an area of investigation that has been relatively neglected in the search for an understanding of oncogenic mechanisms and novel routes to therapy. This proposal seeks to further our understanding of how RNA binding proteins (RBP) regulate fundamental cellular processes and how they are integrated with signaling and transcriptional processes which may be corrupted in cancer.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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