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PhD studentship: The role of PI3K in regulatory T cell function
Reference
BBS/E/B/0000H262
Principal Investigator / Supervisor
Professor Klaus Okkenhaug
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
80,254
Status
Completed
Type
Institute Project
Start date
01/10/2010
End date
30/09/2014
Duration
48 months
Abstract
T cells, so-called because they develop in the thymus, are a type of white blood cell crucial for the function of the immune system. Regulatory T cells (Tregs) are a specialised type of T cell that police the immune system and ensure that immune responses are only raised when necessary. In the complete absence of Tregs, inappropriate activation of the immune system leads to severe autoimmunity and death. We have determined that the enzyme PI3K p110delta is important for Treg function. In this project, we determine what happens if p110delta is inactivated in Tregs only. We will focus on immune responses that occur during colitis (inflammation of the colon) and central nervous system inflammation.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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