Award details

Cancer Research UK Studentship: Defining the function of genes in the immune system

Reference	BBS/E/B/0000H190
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	147,210
Status	Completed
Type	Institute Project
Start date	01/10/2006
End date	31/03/2010
Duration	42 months

Abstract

The B cell is a crucial component of the normal immune system, however its dysregulation can lead to certain types of leukaemia, lymphoma and myeloma. This project aims to establish the role of a gene called TIS11 in the regulation of cell death and differentiation (specialisation) in the B cell. The main focus will be the generation and analysis of a mouse model in which TIS11 is deleted in B cells. We will also test the effects of overexpression of TIS11 in cultured B cells.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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