Award details

'Dying back' pathology in Alzheimer's disease

Reference	BBS/E/B/0000H161
Principal Investigator / Supervisor	Professor Michael Philip Coleman
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	220,986
Status	Completed
Type	Institute Project
Start date	01/08/2005
End date	30/09/2009
Duration	50 months

Abstract

It has recently become clear that a key early event in Alzheimer's disease is the loss of synapses, the points where nerve cells contact one another and exchange information. Synapses lie at the ends of long processes named axons and dendrites, which are a highly vulnerable part of nerve cells. Axons and dendrites also degenerate in Alzheimer's disease and this may contribute to synapse loss. This whole process is called 'dying back', as nerve cells die from their extremities backwards. My laboratory has identified a gene that delays axon degeneration and developed an exciting new method to image degenerating axons. Using these novel approaches, we are taking a fresh look at axon and dendrite damage in Alzheimer's disease, and attempting to delay axon degeneration in Alzheimer's disease models and study the consequences.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Ageing, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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