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The functions of trophoblast-specific proteases in embryonic development
Reference
BBS/E/B/0000H143
Principal Investigator / Supervisor
Dr Myriam Hemberger
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
18,408
Status
Completed
Type
Institute Project
Start date
01/01/2005
End date
31/12/2005
Duration
12 months
Abstract
In mammals, embryonic nutrient supply and waste disposal are carried out by the placenta. Placental function in humans and mice is dependent on the direct contact of placental (trophoblast) cells with maternal blood to ensure efficient transfer capacity. In mice, the cells responsible for establishing this contact are called trophoblast giant cells. They have the ability to invade into the uterus and redirect maternal blood flow. Embryonic development cannot proceed when giant cells fail to differentiate normally. The project investigates the roles of a set of placenta-specific proteases in giant cell function using a mouse model that confers overexpression and/or ectopic expression of these genes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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