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Mechanisms of heterochromatin remodelling for DNA replication

Reference	BBS/E/B/0000H125
Principal Investigator / Supervisor	Dr Patrick Varga-Weisz
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	78,102
Status	Completed
Type	Institute Project
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

The genome is organised and packed by a complicated superstructure called chromatin. The most basic building block of chromatin is the nucleosome, a molecular spool around which DNA winds in two turns. Chromatin remodeling factors are enzymes that render this structure dynamic and regulate all processes that involve the genome, including transcription, DNA replication and DNA repair. One class of chromatin remodeling factors use the energy gained by ATP-hydrolysis to mobilise nucleosomes. We will study how these factors are involved in the replication of DNA and chromatin. This work will reveal mechanisms that are of fundamental importance in the safeguarding of the genome, and therefore, important for our understanding of the oncogenic process. This work may also reveal if ISWI-complexes are potential drug targets to specifically target cancer cells.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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