Award details

The maintenance and function of lymphocytes in the skin

Reference	BBS/E/B/0000H119
Principal Investigator / Supervisor	Dr Marc Veldhoen
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	27,220
Status	Completed
Type	Institute Project
Start date	01/10/2011
End date	30/09/2014
Duration	36 months

Abstract

The immune system is responsible for our protection against invading microorganism such as bacteria and viruses. An initial response is directed against conserved molecules found in many microorganisms without building up long-term protection. This is mediated by cells of the innate immune system. If clearance of the pathogen fails, a more sophisticated response, highly selective against a microorganism in particular and resulting in lifelong protection, is initiated by cells of the adaptive immune system. The latter mainly comprises two types of white blood cells, B and T lymphocytes. However, in recent years an intermediate group of cells has been discovered which do not possess the sophistication of T and B lymphocytes, but do share many of their functional capacities and are derived from the same precursor cells; the innate lymphoid cells (ILCs). These ILCs are a heterogenous collection of cells; each group characterised by particular functional capacities, and make a major contribution to immunity. This project aims to provide insight into particular groups of ILCs found in tissues associated with the intestinal tract. We focus on how these cells develop and contribute to various aspects of (aberrant) immunity.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search