BBSRC Portfolio Analyser
Award details
Role of TET3 in the regulation of epigenetic reprogramming and totipotency
Reference
BBS/E/B/0000H117
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
19,100
Status
Completed
Type
Institute Project
Start date
01/10/2010
End date
30/09/2013
Duration
36 months
Abstract
At the beginning of embryo development (just after fertilization) embryonic cells are totipotent which means they can give rise to all cell types in the body. The epigenetic regulation of totipotency is not understood but is thought to potentially involve reprogramming of epigenetic information carried in egg and sperm in preparation for cells to develop in various directions. We have identified an enzyme called TET3 which is highly expressed in the zygote and whose function at least in part is in removing pre-existing epigenetic information in the form of methylation of DNA. This studentship project will investigate the role of TET3 in potentially regulating totipotency.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search