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CTR studentship: Role of the base excision repair pathway in demethylation of DNA and trophoblast development
Reference
BBS/E/B/0000H112
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
61,705
Status
Completed
Type
Institute Project
Start date
01/10/2009
End date
30/09/2013
Duration
48 months
Abstract
Genetic information is passed from generation to generation and is the material upon which natural selection acts. On top of this genetic information the genome also contains epigenetic information in the form of chemical and other modifications to DNA, which are associated with gene expression and genome function. Epigenetic information is acquired during development and perhaps also dependent on changing environmental conditions. During development of germ cells (egg and sperm) and gametes however there is a process of erasure of such epigenetic information. This may aid embryonic development afresh in the next generation, and eliminate acquired epigenetic information so that it cannot be passed down the generations. The mechanisms of erasure of epigenetic information may partly be based on repair of DNA. We are addressing the mechanisms of erasure in animal models, and how perturbations in this process might affect the development of early embryos.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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