Award details

BRC Fellowship: Regulation of neutrophil apoptosis by the phosphoinositide 3OH-kinases

Reference	BBS/E/B/0000H111
Principal Investigator / Supervisor	Dr Phillip Hawkins
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	104,147
Status	Completed
Type	Institute Project
Start date	01/05/2008
End date	30/04/2011
Duration	36 months

Abstract

Neutrophils are white blood cells that play key roles in our immune system. They represent one of the first lines of defence against invading microbial pathogens, such as bacteria and fungi. Unfortunately, they are also often implicated in unwanted inflammatory reactions when they are recruited to sites of infection/inflammation and turn their anti-microbial weaponry against body tissues, for example in autoimmune diseases such as arthritis and vasculitis, and in response to infections, insults and damage, particularly in the lung (e.g. pneumonia). One of the important processes that limit the lifte-time of neutrophils at sites of inflammation is a regulated cell-destruction process called apoptosis, which if successful leads to the resolution of inflammation through their clearance by cells called macrophages. We are studying how neutrophil apoptosis is regulated by signals found at sites of inflammation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Ageing, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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