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Cambridge Trusts: Regulation and function of the micro RNA miR-675

Reference	BBS/E/B/0000H109
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	136,889
Status	Completed
Type	Institute Project
Start date	01/10/2007
End date	30/09/2010
Duration	36 months

Abstract

RNA has recently been shown to have enormous gene regulatory capacity. Much of the genome is transcribed ('copied') into RNA, and a number of specific classes of non-coding (does not code for protein) RNAs have been defined. Amongst these are the micro RNAs, which are small RNAs that often bind in a complementary fashion to several protein coding RNAs and regulate their stability or translation into protein. We have discovered a new micro RNA, miR-675, which interestingly is produced by a well known non-coding and parentally imprinted RNA gene, H19. Imprinting is when one of the two copies of genes inherited from our parents silenced. We suspect that miR-675 may have an important role in the regulation of fetal growth, cell proliferation, and perhaps certain cancers. This student project takes developmental and genetic approaches to attempt to define the function of miR-675.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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