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Imprinted genes, Prader-Willi Syndrome and Psychotic illness
Reference
BBS/E/B/0000H107
Principal Investigator / Supervisor
Dr Lawrence Wilkinson
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
34,071
Status
Completed
Type
Institute Project
Start date
01/12/2003
End date
30/04/2006
Duration
29 months
Abstract
This is a 5 year collaborative project between the Babraham Institute (Lawrence Wilkinson, Wolf Reik) and the Department of Psychiatry, University of Cambridge (Tony Holland) funded by the Beebe Trust and The Health Foundation. The work will examine the influence of imprinted genes located on human chromosome 15 (15q11-q13) in mediating different aspects of a condition known as Prader-Willi syndrome. In particular, the work will look at the possibility that an overabundance of maternally derived gene product can lead to an increased vulnerability to mental disease in these individuals. Additionally, it is hoped that the experiments will give rise to findings that will be of more general relevance to the well established association of 15q11-q13 with several common mental disorders, including autism, bipolar disorder and schizophrenia.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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