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Award details
MAP kinase activation and tau phosphorylation in mouse models for Alzheimer's disease
Reference
BBS/E/B/0000H105
Principal Investigator / Supervisor
Dr Lawrence Wilkinson
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
85,034
Status
Completed
Type
Institute Project
Start date
01/01/2004
End date
30/06/2007
Duration
42 months
Abstract
The project will use transgenic mouse models for Alzheimer¿s disease (AD) developed at the Babraham Institute in order to examine the idea that molecules called MAP kinases play a key role in the way in which a protein called tau is regulated by a chemical process which adds phosphate groups (phosphorylation). This is important because tau function is abnormal in AD and one of the main ways in which it becomes dysfunctional is by its inappropriate phosphorylation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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