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Development of a novel and accessible mouse model of Parkinson's disease
Reference
BBS/E/B/0000H084
Principal Investigator / Supervisor
Dr Piers Emson
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
80,263
Status
Completed
Type
Institute Project
Start date
01/08/2003
End date
31/07/2007
Duration
48 months
Abstract
In previous work we have developed a novel mouse model of Parkinson¿s disease which has dramatically reduced levels of neurotransmitters in the brain (especially the transmitter missing in Parkinson¿s disease ¿ dopamine). These mice have motor impairments and supersensitive dopamine receptors as found in Parkinson¿s patients. In this project we aim to create an even better model of Parkinson¿s disease (suitable for example for drug screening or testing gene therapy/stem cells) by crossing our existing mouse, with mice we have available which express a mutant form of the human protein alpha-synuclein which accumulates in the dopamine cells of patients with Parkinson¿s disease. The combination of abnormal protein accumulation and impaired dopamine metabolism is believed to result in dopamine cell loss in man, and we hope to produce a mouse model of Parkinson¿s disease with all the hallmarks of human Parkinson¿s disease, with which to further understand the causes of the disease and to investigate novel treatments of Parkinson¿s disease.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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