Award details

Ubiquitination and de-ubiquitination in the regulation of cell signalling

Reference	BBS/E/B/0000H081
Principal Investigator / Supervisor	Dr Peter Kilshaw
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	8,768
Status	Completed
Type	Institute Project
Start date	01/05/2003
End date	30/09/2004
Duration	17 months

Abstract

Rejection of transplanted kidneys occurs when immune cells from the recipient attack the donor organ. Endothelial cells, which line the inner surface of blood vessels, constitute a barrier between the donor tissue and the recipient¿s circulating immune cells. The production of particular proteins by endothelial cells is known to alter their properties. Some molecules, such as NF-?B, trigger endothelial cells to become permissive to recipient immune cells, which leads to rejection. In contrast, endothelial cell production of a `protective¿ molecule called A20 has been associated with prolonged survival of transplanted organs. A20 is known to suppress the activity of the pro-inflammatory molecule NF-?B and also to prevent endothelial cell death. Our recent findings have revealed a new biological activity for A20 which may explain its protective effects

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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