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Defining the role of the RhoG GTPase in differentiation proliferation and apoptosis

Reference	BBS/E/B/0000H003
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	95,514
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2004
Duration	36 months

Abstract

Small GTPases of the Rho family play pivotal roles in signal tranduction pathways controlling proliferation, differentiation and death. A greater understanding of these processes as well as their subversion in cancer should permit the development of new therapeutic approaches. RhoG has been shown to possess transforming potential and to synergise with Ras to promote foci formation. The function of RhoG is thus relevant to the transformed phenotype. This proposal seeks to define the function of RhoG in vivo using gene targeting technology. The proposed study focuses on the role of RhoG in lymphocyte development and function. This is an appropriate system for the study of RhoG function because we have found RhoG has a role in the antigen receptor signalling pathway of lymphocytes. The in vivo approach will permit us to establish the function of RhoG in proliferation, differentiation and cell death.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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