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Imprinting of Igf2: role of repressors and silencers and relevance to Beckwith-Wiedemann cancer syndrome
Reference
BBS/E/B/0000H001
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
158,172
Status
Completed
Type
Institute Project
Start date
01/03/2001
End date
31/03/2004
Duration
37 months
Abstract
One of the genes which is important for growth of babies in the womb is Igf2. If this gene is not properly shut off in children and in adults, it may be able to cause cancers. We are studying a regulatory region in Igf2 which may be required for shutting off the gene. We are altering this region to see whether Igf2 is regulated differently, and whether these mice have a higher risk of developing cancer. This model may lead to important diagnostic and therapeutic applications.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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