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Portugese Government funded studentship: A new factor linking chromatin remodelling to DNA repair
Reference
BBS/E/B/0000F136
Principal Investigator / Supervisor
Dr Patrick Varga-Weisz
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
10,437
Status
Completed
Type
Institute Project
Start date
01/10/2004
End date
14/12/2007
Duration
38 months
Abstract
The genetic information, the genome, is organized and packed by a complicated superstructure called chromatin. The most basic building block of chromatin is the nucleosome, a molecular spool around which the DNA winds in two turns. Chromatin remodelling factors are enzymes that render this structure dynamic and regulate all processes that involve the genome, including transcription, DNA replication and DNA repair. One class of chromatin remodelling factors use the energy gained by ATP-hydrolysis to mobilise nucleosomes or other nucleo-protein complexes. We study how the modification of chromatin proteins, especially histones, links to and regulates such ATP-dependent chromatin remodelling by characterising a novel chromatin remodelling factor that is involved in DNA repair and chromosome maintenance.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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