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Interaction partners for the GIMAP proteins
Reference
BBS/E/B/0000C241
Principal Investigator / Supervisor
Dr Geoff Butcher
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
221,183
Status
Completed
Type
Institute Project
Start date
01/02/2010
End date
31/03/2012
Duration
26 months
Abstract
Studies of genetically-altered strains of rats and mice have demonstrated that genes of the GIMAP family play important roles in the development of mature lymphocyte (a type of white blood cell) populations and possibly also in their homeostasis. In some cases, mutation of these genes can lead to autoimmunity e.g. type 1 diabetes; inflammatory bowel disease. This project aims to uncover the mechanisms of action of this family of proteins which is preferentially found in the immune system. Success in this direction could lead to novel therapeutic opportunities for the control of lymphocytes in autoimmunity or in the context of transplantation.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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