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Cell fate decisions: the role of PRC1-like complexes in stem cell differentiation

Reference	BBS/E/B/0000C239
Principal Investigator / Supervisor	Dr Jennifer Pell
Co-Investigators / Co-Supervisors	Dr Sarah Elderkin
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	112,065
Status	Completed
Type	Institute Project
Start date	01/10/2009
End date	31/03/2012
Duration	30 months

Abstract

The protein complex called PRC1 is thought to have a key role in dictating cell fate, by inducing changes in chromatin structure that are associated with gene slicencing. Chromatin is the combination of DNA and proteins that form chromosomes. This is being investigated in preliminary studies in muscle adult stem cells. When activated (e.g. by an injury, or a stimulus for growth), these cells must proliferate and make the 'decision' to either differentiate (specialise) further into a muscle cell, or to remain/return to a stem cell type.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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