BBSRC Portfolio Analyser
Award details
Selection of the antibody repertoire
Reference
BBS/E/B/0000C229
Principal Investigator / Supervisor
Dr Inga-Lill Martensson-Bopp
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
478,210
Status
Completed
Type
Institute Project
Start date
01/04/2007
End date
31/03/2009
Duration
24 months
Abstract
B lymphocytes synthesise antibodies which make up our humoral immune response. Antibodies bind specifically to foreign antigens found on bacteria and viruses, which can then be disposed of by different routes. Individuals that lack antibodies are severely immuno-deficient and cannot clear the body of any infection that needs the assistance of antibodies. Antibodies can also be pathogenic, which is often the case when an antibody recognises auto (self) antigen; if severe this can lead to destruction of a particular tissue (autoimmunity). B lymphocytes can also become tumorigenic and a large proportion of adult lymphoid malignancies are of B lymphocyte origin. It follows that a greater understanding of the biological systems and processes that lead to proper development of B lymphocytes is of utmost importance. This increased understanding will provide insights that are relevant to, and can be exploited by, biomedicine.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search