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The role of the ARAP families of PI3K effectors in the regulation of the cytoskeleton

ReferenceBBS/E/B/0000C219
Principal Investigator / Supervisor Dr Phillip Hawkins
Co-Investigators /
Co-Supervisors
Institution Babraham Institute
DepartmentBabraham Institute Department
Funding typeResearch
Value (£) 419,705
StatusCompleted
TypeInstitute Project
Start date 01/12/2004
End date 30/11/2007
Duration36 months

Abstract

Cells need to adapt their shape during processes like movement or phagocytosis. This changes involve many different aspects of the cells molecular machinery and must be appropriately and synchronously adjusted. This project is focussed on a family of molecules (ARAP) that are involved in the spatio/temporal synchronisation of shape change. Our hypothesis is that they cause simultaneous reduction in the local tension of the scaffold at the cell surface (enabling protusion to occur) with increased delivery of new membrane to the areas undergoing protusion.

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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