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The role of the ARAP families of PI3K effectors in the regulation of the cytoskeleton
Reference
BBS/E/B/0000C219
Principal Investigator / Supervisor
Dr Phillip Hawkins
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
419,705
Status
Completed
Type
Institute Project
Start date
01/12/2004
End date
30/11/2007
Duration
36 months
Abstract
Cells need to adapt their shape during processes like movement or phagocytosis. This changes involve many different aspects of the cells molecular machinery and must be appropriately and synchronously adjusted. This project is focussed on a family of molecules (ARAP) that are involved in the spatio/temporal synchronisation of shape change. Our hypothesis is that they cause simultaneous reduction in the local tension of the scaffold at the cell surface (enabling protusion to occur) with increased delivery of new membrane to the areas undergoing protusion.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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