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Functional analysis of genomic imprinting at the maternal-fetal interface - implications for fetal growth and development
Reference
BBS/E/B/0000C215
Principal Investigator / Supervisor
Dr Miguel Constancia
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
117,382
Status
Completed
Type
Institute Project
Start date
01/08/2004
End date
31/07/2005
Duration
12 months
Abstract
Imprinted genes are major regulators of fetal and placenta development and growth. Although numerous studies in mice have demonstrated the importance of imprinted genes in placental development and growth, very little is known about their function in this important organ. This project is aimed at understanding the role of imprinting in extra-embryonic tissues and in particular the role of these genes in supplying maternal nutrients to the mammalian embryo. De-regulation of supply of maternal nutrients has important implications for the growth of the fetus with consequences in the neonatal period and long term consequences in adulthood.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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