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Award details
Innate immunity to infections and cancer
Reference
BBS/E/B/0000C212
Principal Investigator / Supervisor
Professor Francesco Colucci
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
1,699,205
Status
Completed
Type
Institute Project
Start date
01/09/2004
End date
31/08/2009
Duration
60 months
Abstract
Thirty years ago white blood cells capable of killing tumours were discovered in the laboratory. Because the killing process was spontaneous, these lymphocytes were called Natural Killer (NK) cells. Later it was discovered that they can also deliver anti-microbial and pro-inflammatory factors that guide other cells to specific and long-lasting immunity. Today we know that NK cells are armed with an array of surface receptors that enable them to detect and swiftly destroy malignant and infected cells in the body. Our group is interested in understanding how these receptors start the molecular events that activate NK cell immunity to infections and tumours. A better characterisation of immune pathways that control infections and cancer will provide a rational basis to develop alternative therapeutic strategies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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