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Signalling pathways regulating adult muscle stem cell function and myogenesis

Reference	BBS/E/B/0000C170
Principal Investigator / Supervisor	Dr Jennifer Pell
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	2,309,170
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2012
Duration	108 months

Abstract

Muscle is composed of bundles of highly structurally organized proteins, collectively termed myofibres. Myofibre number is largely determined by birth and all subsequent muscle growth occurs by each fibre enlarging. Specialised cells, known as satellite cells (a form of adult stem cell) are responsible for generating precursor muscle cells that will enable fibre growth and also muscle repair. Animals lacking satellite cells die. It is therefore important to understand satellite cell function in terms of: i, their ability to become active and to proliferate, ii, their subsequent differentiation (specialisation) into muscle and iii, their ability to replace themselves.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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