BBSRC Portfolio Analyser
Award details
Neural network signalling, plasticity and learning
Reference
BBS/E/B/0000C166
Principal Investigator / Supervisor
Professor Keith Kendrick
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
712,567
Status
Completed
Type
Institute Project
Start date
01/06/1999
End date
31/03/2011
Duration
142 months
Abstract
We need to understand the mechanisms whereby the brain learns and remembers information to control cognitive and emotional behaviour if we are going to be able to develop therapies for treating cognitive dysfunction associated with developmental, psychiatric and neurodegenerative disorders. This project aims to use technologies for recording the activity of large-scale neural networks in the rodent brain combined with computational, mathematical and modelling approaches to help establish general principles of how learning alters the way information is encoded by these networks and the key signalling molecules involved. Neuronal cell culture approaches will also be used where appropriate. By developing modelling approaches we will be able to use computer simulations both to help interpret the biological data and to refine and reduce the requirement for animal experiments. This project directly addresses the BBSRC strategic research priority in 'Basic bioscience underpinning health' and will help develop new drug targets and pharmaceuticals to aid treatment of human cognitive disorders. By using an integrative, systems biology approach using mathematical tools and modelling to aid understanding of how learning alters signalling in large scale neural networks it also directly addresses the BBSRC enabling theme: 'Exploiting new ways of working'.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Neuroscience and Behaviour
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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