Award details

Regulation of chromatin accessibility in haematopoietic lineage commitment

Reference	BBS/E/B/0000C163
Principal Investigator / Supervisor	Dr Anne Corcoran
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	1,824,540
Status	Completed
Type	Institute Project
Start date	03/05/2000
End date	31/03/2012
Duration	143 months

Abstract

Different types of cells are characterised by the different proteins that they make and these differences depend on which parts of their DNA are unfolded to switch on their respective genes, which encode the proteins. We want to understand how this unfolding process is regulated to ensure that the right genes are made accessible in the right cells. We are studying this question in B lymphocytes. These cells make the large numbers of antibodies the immune system needs to fight infection. This process involves joining a limited number of antibody genes in many different combinations. The DNA that makes up these genes is usually tightly packaged and must be unfolded to allow access to the genes. Otherwise the individual cannot make enough different antibodies. This project aims to understand the mechanisms that make antibody genes safely available for this process. It will also help us to understand general methods used by cells to ensure they activate the correct genes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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