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The role of Cdx protein phosphorylation in colorectal carcinoma cells
Reference
BBS/E/B/0000C162
Principal Investigator / Supervisor
Dr Stephen Gaunt
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
164,581
Status
Completed
Type
Institute Project
Start date
01/04/2009
End date
31/03/2012
Duration
36 months
Abstract
Cdx1 and Cdx2 are proteins that regulate the normal growth and differentiation (specialisation) of the intestinal epithelium (the outer layer of cells of the intestine). Both proteins are suppressed in colorectal carcinoma (CRC) and it is believed that this contributes to the progression of malignancy. We have shown that degradation of Cdx2 protein in CRC cells is signalled by its prior phosphorylation (the addition of phosphate). We have also shown that Cdx1 is phosphorylated and we next intend to examine whether this is a signal for degradation or activation of the Cdx1 protein. Our findings will have additional value since Cdx1 and 2 are also important regulators of the developing embryonic axis.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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