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Award details
Role of sperm proacrosin during fertilisation
Reference
BBS/E/B/0000C158
Principal Investigator / Supervisor
Dr Roy Jones
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
614,657
Status
Completed
Type
Institute Project
Start date
01/04/2003
End date
31/10/2008
Duration
67 months
Abstract
This project aims to understand how spermatozoa are able to recognise and bind to eggs in such a specific way. By identifying the molecules on respective gametes that are responsible for this process, we should be able to design drugs that interfere with it and that would form the basis for a new generation of antifertility agents for human and animal use. Proacrosin is a protein found within the acrosomal vesicle of all mammalian spermatozoa. Recently, we have shown that it has a role in fertilisation in binding acrosome-reacted sperm to the zona pellucida. This project aims to use a multidisciplinary approach to establish a physiological role for proacrosin/acrosin.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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