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Accessory protein regulation of Inositol 1,4,5-trisphosphate receptor signalling and its downstream consequences
Reference
BBS/E/B/0000C116
Principal Investigator / Supervisor
Prof. Llewelyn Roderick
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
522,259
Status
Completed
Type
Institute Project
Start date
01/01/2005
End date
31/03/2012
Duration
87 months
Abstract
Changes in calcium ion, Ca2+, levels inside cells regulate diverse cellular processes, including fertilisation, gene transcription (the copying of DNA information into RNA), muscle contraction, and cell death. Increases in Ca2+ inside cells arise either as a result of its release from calcium stores within the cell or by influx across the membrane that surrounds the cell. Both chemical and electrical signals can trigger these increases in Ca2+ concentration. The importance of carefully regulating Ca2+ is underlined by the consequences of its mis-regulation: stroke, irregular heart beats and heart failure, high blood pressure, some neurodegenerative diseases and cancer are all associated with aberrant Ca2+ signalling. My aim is to identify novel modes of regulation of calcium levels inside cells. This will subsequently provide insight into the interplay between cell signalling pathways and will establish novel links between the calcium signalling pathway and other pathway inside the cell.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Neuroscience and Behaviour
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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