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Accessory protein regulation of Inositol 1,4,5-trisphosphate receptor signalling and its downstream consequences

ReferenceBBS/E/B/0000C116
Principal Investigator / Supervisor Prof. Llewelyn Roderick
Co-Investigators /
Co-Supervisors
Institution Babraham Institute
DepartmentBabraham Institute Department
Funding typeResearch
Value (£) 522,259
StatusCompleted
TypeInstitute Project
Start date 01/01/2005
End date 31/03/2012
Duration87 months

Abstract

Changes in calcium ion, Ca2+, levels inside cells regulate diverse cellular processes, including fertilisation, gene transcription (the copying of DNA information into RNA), muscle contraction, and cell death. Increases in Ca2+ inside cells arise either as a result of its release from calcium stores within the cell or by influx across the membrane that surrounds the cell. Both chemical and electrical signals can trigger these increases in Ca2+ concentration. The importance of carefully regulating Ca2+ is underlined by the consequences of its mis-regulation: stroke, irregular heart beats and heart failure, high blood pressure, some neurodegenerative diseases and cancer are all associated with aberrant Ca2+ signalling. My aim is to identify novel modes of regulation of calcium levels inside cells. This will subsequently provide insight into the interplay between cell signalling pathways and will establish novel links between the calcium signalling pathway and other pathway inside the cell.

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsNeuroscience and Behaviour
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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