Award details

The development and homeostasis of lymphocyte populations

Reference	BBS/E/B/0000C042
Principal Investigator / Supervisor	Dr Geoff Butcher
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	3,420,512
Status	Completed
Type	Institute Project
Start date	01/04/2004
End date	31/03/2012
Duration	96 months

Abstract

Lymphocytes are a type of white blood cell and are the key players in the immune response. Individual variations in the ability to make particular immune responses, or in their quality, are often due to lymphocytes and their products. Similarly, lymphocytes are often the culprits in autoimmune disease, where they make inappropriate, damaging responses. This project aims to investigate some of the factors underlying the development and stability of lymphocyte populations and the consequences of their malfunction. We originally focussed on the lymphopenia mutation in rats which is a strong determinant of autoimmune disease (e.g. Type 1 diabetes in the BB rat model and, in our own work, a form of inflammatory bowel disease). Once this mutation was shown to be located in a gene encoding a GTPase protein called GIMAP5, we turned our attention more widely to the biology of the family of GIMAP GTPases.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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