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The effect of pulsed radiofrequency electromagnetic fields on redox signalling and calcium homeostasis

Reference	BBS/E/B/0000B045
Principal Investigator / Supervisor	Dr Martin Bootman
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	25,309
Status	Completed
Type	Institute Project
Start date	01/01/2002
End date	31/07/2005
Duration	43 months

Abstract

Following the publication of the Stewart report, the Independent Expert Group on Mobile Phones recommended further research to investigate the sub-cellular and cellular changes induced by RF radiation and their possible impact on health. A number of investigators have suggested that RF-EMF exposure might affect biological systems by influencing redox signalling pathways that use free radicals, or through direct effects on cellular calcium homeostasis. Thus, determining the extent to which redox signalling and calcium homeostasis might be involved in RF-EMF potential bioeffects is extremely important. Any effects that RF-EMF might have upon the redox signalling axis of cells, or the ability of cells to adapt to nitrosative or oxidative stress, would be of considerable importance in estimating the possible health effects of mobile phones considering the well known role of nitric oxide and reactive oxygen species in the permeability of the blood brain barrier, headache and memory. For this reason, we propose to construct an exposure system around a versatile high-throughput homogenous imaging system (AutoLead¿ Cell Analyzer, Imaging Research Inc., Canada). This approach will facilitate the rapid assay of several types of tissues samples with maximal precision to achieve in vitro results that will be generalizeable to the possible health effects of RF-EMF. The automation of this process will minimize the possibility of bias and produce results that can be used with epidemiology and in vivo results to determine future DOH RF-EMF exposure policy.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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