Award details

Innate immunity to infections and cancer

ReferenceBBS/E/B/00001212
Principal Investigator / Supervisor Professor Francesco Colucci
Co-Investigators /
Co-Supervisors
Institution Babraham Institute
DepartmentBabraham Institute Department
Funding typeResearch
Value (£) 166,944
StatusCompleted
TypeInstitute Project
Start date 01/09/2004
End date 31/08/2009
Duration60 months

Abstract

Thirty years ago white blood cells capable of killing tumors were discovered in the laboratory. Because the killing process was spontaneous, these lymphocytes were called Natural Killer (NK) cells. Later it was discovered that they can also deliver anti-microbial and pro-inflammatory factors that guide other cells to specific and long-lasting immunity. Today we know that NK cells are armed with an array of surface receptors that enable them to detect and swiftly destroy malignant and infected cells in the body. Our group is interested in understanding how these receptors start the molecular events that activate NK cell immunity to infections and tumors. A better characterization of immune pathways that control infections and cancer will provide a rational basis to develop alternative therapeutic strategies.

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsImmunology
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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