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Comparative genomics and bioinformatics of imprinted gene cluster on 11p15.5
Reference
BBS/E/B/00001211
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
222,460
Status
Completed
Type
Institute Project
Start date
01/04/2004
End date
31/03/2005
Duration
12 months
Abstract
A number of genes which are important for growth and development of babies in the womb are imprinted, that is only the maternal or paternal gene is effective. It is thought that this genetic mechanism evolved in mammals with the placenta, which provides maternal nutrients to the growing fetus. Imprinted genes are clustered in particular regions of the genome, and we are studying one such cluster which has strong effects on growth of the baby in normal development and in human diseases. In order to understand the evolution of these genes, we are establishing the sequence of their DNA in a number of mammalian species, including egg-laying ones (monotremes), and those with quite a different type of placenta (marsupials).
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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