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The role of PI3K, GEFs and GTPase in chemotaxis and the respiratory burst

Reference	BBS/E/B/00001207
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	243,119
Status	Completed
Type	Institute Project
Start date	15/07/2003
End date	15/07/2006
Duration	36 months

Abstract

The mechanisms by which cells migrate or chemotax towards specific extracellular transmitters are not well understood. The most tractable mammalian models are neutrophils and macrophages and their ability to move towards sources of various inflammatory mediators. These responses are a vital part of normal responses to damage and/or infection. Because inappropriate inflammatory reactions are causative in a number of economically and medically important diseases such as sepsis and rheumatoid arthritis, the process of leukocyte chemotaxis has become widely recognised in the pharmaceutical sector as a target for therapeutic intervention.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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