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New molecules in signalling pathways for lymphocyte development

Reference	BBS/E/B/00001206
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	429,224
Status	Completed
Type	Institute Project
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

Developing new approaches to manipulate the mammalian immune system represents one of the major challenges for the biotechnology and biological sciences community in the 21st century. The increases in allergic and autoimmune disease coupled with the threat of new and re-emerging infectious diseases means that we must develop strategies which either restrain or augment the function of immune cells. This challenge can only be met if we have a complete understanding of the signal transduction mechanisms activated by encounter with antigen. Consequently, the biochemical and genetic pathways triggered by antigen encounter are the subject of study in our project. Expression of individual members of signalling molecules is regulated during lymphocyte development and thus imparts considerable flexibility upon the antigen receptor in terms of the molecules which it can recruit and activate during the lifetime of the lymphocyte. Evaluation of the role of these molecules in lymphocytes is necessary to understand how activation thresholds of the antigen receptor are set.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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