Award details

Analysis of TRPM function in Drosophila

Reference	BBS/E/B/00001203
Principal Investigator / Supervisor	Professor Raghu Padinjat
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	76,949
Status	Completed
Type	Institute Project
Start date	01/04/2004
End date	28/02/2005
Duration	11 months

Abstract

The TRP family of ion channels are ubiquitous mediators of calcium influx in eukaryotic cells that are conserved from yeast through to humans. Four families of TRP channels have been discovered; one of these the TRPM family has eight vertebrate homologs and is unique in that some of these proteins contain a channel domain fused to a C-terminal enzymatic domain (phosphatases and kinase domain) although the functional significance of these enzymatic domains is unknown. TRPM channels have been implicated in tumor metastasis, neurodegeneration via oxidative stress and may be required for cell viability. Despite numerous recent advances in the study of TRPM channels their mechanism of activation and their function in-vivo remain enigmatic. During this studentship, we propose to carry out an in-vivo functional analysis of the only TRPM gene in the Drosophila.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search