Award details

Activation of Drosphila TRP channels: role of lipid messengers in regulating calcium influx

Reference	BBS/E/B/00001185
Principal Investigator / Supervisor	Professor Raghu Padinjat
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	157,502
Status	Completed
Type	Institute Project
Start date	12/01/2002
End date	31/12/2004
Duration	36 months

Abstract

Numerous human and animal diseases are thought to arise from defective Signal Transduction, the internal chemical language that cells use to monitor their surroundings and talk to other cells. Calcium ions are an important and widespread component of this chemical language used by animal cells. The main interest in our group is to understand how cells regulate intracellular calcium levels. Calcium is a second messenger that plays an important role in diverse biological processes such as fertilization, development and cell division. Understanding how calcuim signalling is regulated has implications for the treatment of heart disease, immune system dysfunction, stroke and neurodegenerative diseases. This project uses genetic analysis in the fruitfly Drosophila to understand how intracellular calcuim levels are regulated in animal cells.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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