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Characterisation of novel phosphoinositide 3-kinase/PtdIns(3,4,5)P3 signal transduction elements

ReferenceBBS/E/B/00001182
Principal Investigator / Supervisor Dr Phillip Hawkins
Co-Investigators /
Co-Supervisors
Institution Babraham Institute
DepartmentBabraham Institute Department
Funding typeResearch
Value (£) 275,626
StatusCompleted
TypeInstitute Project
Start date 01/04/2002
End date 31/03/2005
Duration36 months

Abstract

The phosphoinositide 30H-kinase / PtdIns(3,4,5)P3 signalling system is of critical importance in normal cell function and also plays an important role under pathological conditions. Currently, the major barrier to understanding how PtdIns(3,4,5)P3 regulates cellular processes, and hence which proteins represent the best target for drugs, is a paucity of information about the direct PtdIns(3,4,5)P3 binding proteins or effectors. Our research involves the identification and characterization of novel, intracellular PtdIns(3,4,5)P3 receptors, and to subsequently attempt to derive which cellular processes they control.

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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