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Mechanisms of neurogenesis from embryonic stem cells

Reference	BBS/E/B/00001172
Principal Investigator / Supervisor	Dr Nicholas Allen
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	329,902
Status	Completed
Type	Institute Project
Start date	01/10/2000
End date	30/09/2003
Duration	36 months

Abstract

The development of stem cell technologies raises enormous potential for the use of stem cells and their tissue derivatives to be used as cell therapies for degenerative disease or tissue repair. Embryonic stem cells are unique amongst stem cells in the degree of pluripotency that they exhibit. At the earliest stages of ES cell differentiation, cells become restricted in their ability to contribute to tissues derived from the principle germ layers the ectoderm, mesoderm or endoderm. We have recently established a model for the generation of neural tissue from ES cells in vitro however the mechanisms by which this differentiation occurs is still poorly understood. A better understanding of the developmental process will aid future studies designed to generate neural tissue with specific phenotypes and hence of potential value for specific therapeutic purposes. This project aims to better understand the earliest stages of ES cell differentiation by defining changes in the profile of expressed genes (transcriptome) and proteins (proteome) present in cells in the first 48 hours after initiating differentiation.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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