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Does the VpreB1 and/or lambda 5 enhancer drive tissue- and stage-specific expression in vivo
Reference
BBS/E/B/00001171
Principal Investigator / Supervisor
Dr Inga-Lill Martensson-Bopp
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
967,840
Status
Completed
Type
Institute Project
Start date
01/10/2000
End date
28/02/2005
Duration
53 months
Abstract
B lymphocytes synthesise antibodies which make up our humoral immune response. Antibodies bind specifically to foreign antigens found on bacteria and viruses, which can then be disposed of by different routes. Individuals that lack antibodies are severely immuno-deficient and cannot clear the body of any infection that needs the assistance of antibodies. Antibodies can also be pathogenic, which is often the case when an antibody recognises auto (self) antigen; if severe this can lead to destruction of a particular tissue (autoimmunity). B lymphocytes can also become tumorigenic and a large proportion of adult lymphoid malignancies are of B lymphocyte origin. It follows that a greater understanding of the biology of B lymphocytes will provide insights which are relevant to, and can be exploited by, biomedicine.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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