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Recognition of MHC encoded structures by receptors on natural killer cells
Reference
BBS/E/B/00001152
Principal Investigator / Supervisor
Dr Geoff Butcher
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
721,665
Status
Completed
Type
Institute Project
Start date
31/10/1998
End date
28/02/2005
Duration
76 months
Abstract
Certain specialised types of white blood cells enable vertebrate animals to make immediate defence responses against infections and possibly also against newly arising cancers. One of the cell types that does this is called the Natural Killer (NK) cell and cells of this type are known to be crucial for defence against certain viruses such as cytomegalovirus and probably other herpes viruses. NK cells can recognise changes to the surface of normal tissue cells which reveal infection or malignant transformation and then kill them, thereby limiting the spread of infection within the body. The project aims to identify the molecules on tissue cells which indicate to NK cells whether they are in a normal or an abnormal/infected state.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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